T. N. Bhat

Biochemical Science Division, CSTL
NIST, 100 Bureau Drive
Gaithersburg, MD 20899


Biography:
Dr. Bhat's areas of research interests are X-ray crystallography, chemical ontology, data validation and data annotation, software development, bioinformatics, AIDS research and Semantic Web. At present, Dr. Bhat is a project leader for the bioinformatics efforts at the Biochemical Science Division of NIST. He is the author of over 80 refereed scientific articles. These publications have received over 8000 scientific citations and it is one of the top hits among the scientific publications from NIST. He was a key person who established the RCSB Protein Data Bank (http://www.rcsb.org/pdb/). Some of his recent database efforts are - AIDS database (HIVSDB) at NIST, http://xpdb.nist.gov/hivsdb/hivsdb.html and re-engineered an existing database (http://xpdb.nist.gov/enzyme_thermodynamics/ ) and http://bioinfo.nist.gov/hmpd/

Talk Title: Semantic Web for Chemical and Cell Images

Abstract: Semantic Web concepts and RDF (Resource Description Framework) friendly data representation methods are of great interest for the growing information technology needs. My talk will focus on our efforts to develop these concepts for structural and cell image informatics. Step1. Develop use case and scenarios for the application of interest. Step2. Develop vocabulary to describe these use cases and concepts. Step3. Establish relationships in the form of RDF to present the use cases using the vocabulary. Step4. Establish views to group these concepts and RDF by forming 'a basket of vocabulary' that combines many elements of the RDF into one group. Step5. Organize the views in a data-tree and present it to users in a predictable fashion preferably over the Web. Our work that uses these steps to present chemical structures has been posted at http://bioinfo.nist.gov/SemanticWeb_int2d/chemblast.do I will also give a progress report on our recent effort to extend these concepts to cell images.